Enfermedades autoinmunes que comprometen nariz, cavidad oral y piel: revisión crítica ORL-dermatológica

Aldwin José Triana-Pomare; Monica Viviana Diaz-Muñoz; Karen Vanessa Alférez-Alvarado; Jhon Alexander Alfonso-Rodríguez; Juan Carlos Alfonso-Rodriguez; Andrea Cecilia Beltran-Villarraga; Laura Camila Millán-Guerrero; Vivian Aurora Céspedes-Martínez; Andrea Marcela Montoya-Medina

Authors

Triana-Pomare Aldwin José Universidad del Cauca. Popayán, Colombia. https://orcid.org/0009-0003-8637-0909
Diaz-Muñoz Monica Viviana Universidad de Antioquia. Medellín, Colombia. https://orcid.org/0009-0001-3806-3993
Alférez-Alvarado Karen Vanessa Universidad Cooperativa de Colombia. Villavicencio, Colombia. https://orcid.org/0009-0001-8271-9048
Alfonso-Rodríguez Jhon Alexander Universidad Cooperativa de Colombia. Villavicencio, Colombia. https://orcid.org/0009-0001-8866-456X
Alfonso-Rodriguez Juan Carlos Universidad Cooperativa de Colombia. Villavicencio, Colombia. https://orcid.org/0009-0007-2798-0933
Beltran-Villarraga Andrea Cecilia Fundación Universitaria Sanitas. Bogotá, Colombia. https://orcid.org/0009-0007-3245-9448
Millán-Guerrero Laura Camila Pontificia Universidad Javeriana. Bogotá, Colombia. https://orcid.org/0009-0001-3000-1130
Céspedes-Martínez Vivian Aurora Unidad Central del Valle del Cauca. Tuluá, Colombia. https://orcid.org/0009-0001-1771-1656
Montoya-Medina Andrea Marcela Universidad Libre seccional Cali. Cali, Colombia. https://orcid.org/0009-0005-1588-9142

Keywords:

Systemic lupus erythematosus; Dermatomyositis; Sjögren’s syndrome; Pemphigus vulgaris; Mucous membrane pemphigoid

Abstract

DOI: https://doi.org/10.46296/gt.v9i17.0340

Abstract

Systemic autoimmune diseases often present with skin and mucosal lesions in the nasal or oral cavity that may precede or reflect overall disease activity. This article provides a critical review of five key entities: systemic lupus erythematosus, dermatomyositis, Sjögren’s syndrome, pemphigus (vulgaris and foliaceus), and mucous membrane pemphigoid. We examine their otorhinolaryngologic and dermatologic manifestations, highlighting clinicopathologic correlations between cutaneous and mucosal lesions as markers of systemic disease activity. We also discuss prognostic factors according to dermatologic patterns – for example, extensive mucosal involvement associated with more severe disease – and the importance of combined skin and mucosal biopsy for early definitive diagnosis. Current recommendations for multidisciplinary management and recent therapeutic advances (such as biologic therapy in pemphigus) that have improved outcomes are included. This review, grounded in literature from the past decade, emphasizes the need for a combined dermatology–rheumatology–ENT approach to optimize the detection and treatment of these uncommon but potentially severe diseases.

Keywords: Systemic lupus erythematosus; Dermatomyositis; Sjögren’s syndrome; Pemphigus vulgaris; Mucous membrane pemphigoid.

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