ASSOCIATION BETWEEN LOSARTAN TREATMENT AND LOWER LIMB PAIN IN ADULT WOMEN AT THE DEPORMED CLINIC
Keywords:
Medication preparation; nursing professionals; patient safety; intravenous administration; nursing practicesAbstract
DOI: https://doi.org/10.46296/gt.v9i18edespsep.0430
Abstract
Lower limb pain may occur in adult women with hypertension receiving pharmacological treatment, although its origin may be related to multiple clinical conditions. The objective was to characterize sociodemographic and clinical conditions, describe losartan treatment characteristics and pain manifestations, and analyze the relationship between treatment characteristics and pain intensity. A quantitative, observational, analytical, cross-sectional study was conducted based on the review of medical records of 99 women aged 20 to 65 years treated at the DEPORMED Clinic during July and August 2026. Sociodemographic variables, body mass index, diabetes, musculoskeletal and neurological conditions, losartan treatment modality and duration, pain intensity according to the visual analog scale, and associated clinical manifestations were analyzed. Absolute frequencies and percentages were calculated. The relationship between treatment characteristics and pain intensity was assessed using Pearson’s chi-square test, with statistical significance set at p<0.05. Women aged 46–65 years (52.5%), those with overweight (56.5%), and those without diabetes (72.7%) predominated. The main concomitant conditions were disc herniation (89.9%), lumbar spinal stenosis (83.8%), and sciatic nerve alterations (78.8%). Treatment was mainly administered as monotherapy (76.8%) and for 3–5 years (52.5%). Severe pain was the most frequent intensity (52.2%), accompanied by cramps (44.4%). No significant association was found between treatment modality and pain intensity (p=0.198), or between treatment duration and pain intensity (p=0.180). The findings suggest a multifactorial context of pain and do not allow causality to be established between losartan treatment and the observed manifestations.
Keywords: Medication preparation; nursing professionals; patient safety; intravenous administration; nursing practices.
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References
Consejo Nacional de Salud, & Comisión Nacional de Medicamentos e Insumos. (2022). Cuadro nacional de medicamentos básicos (11.ª revisión). Ministerio de Salud Pública del Ecuador.
DailyMed. (2012). COZAAR—Losartan potassium tablet, film coated. U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9199238d-8b24-4ca8-bd24-c200853416f6
Dzakpasu, F., Carver, A., Brakenridge, C., Cicuttini, F., Urquhart, D., Owen, N., & Dunstan, D. W. (2021). Musculoskeletal pain and sedentary behaviour in occupational and non-occupational settings: A systematic review with meta-analysis. International Journal of Behavioral Nutrition and Physical Activity, 18, 159. https://doi.org/10.1186/s12966-021-01191-y
Garcia, M. M., Corrales, P., Huerta, M. Á., Czachorowski, M. J., López-Miranda, V., Medina-Gómez, G., Cobos, E. J., Goicoechea, C., & Molina-Álvarez, M. (2024). Adults with excess weight or obesity, but not with overweight, report greater pain intensities than individuals with normal weight: A systematic review and meta-analysis. Frontiers in Endocrinology, 15, 1340465. https://doi.org/10.3389/fendo.2024.1340465
Gloviczki, P., Lawrence, P. F., Wasan, S. M., Meissner, M. H., Almeida, J., Brown, K. R., Bush, R. L., Di Iorio, M., Fish, J., Fukaya, E., Gloviczki, M. L., Hingorani, A., Jayaraj, A., Kolluri, R., Murad, M. H., Obi, A. T., Ozsvath, K. J., Singh, M. J., Vayuvegula, S., ... Welch, H. J. (2024). The 2023 Society for Vascular Surgery, American Venous Forum, and American Vein and Lymphatic Society clinical practice guidelines for the management of varicose veins of the lower extremities. Part II: Endorsed by the Society of Interventional Radiology and the Society for Vascular Medicine. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 12(1), 101670. https://doi.org/10.1016/j.jvsv.2023.08.011
Katz, J. N., Zimmerman, Z. E., Mass, H., & Makhni, M. C. (2022). Diagnosis and management of lumbar spinal stenosis: A review. JAMA, 327(17), 1688–1699. https://doi.org/10.1001/jama.2022.5921
Li, C.-Y., Lin, W.-C., Lu, C.-Y., Chung, Y.-S., & Cheng, Y.-C. (2022). Prevalence of pain in community-dwelling older adults with hypertension in the United States. Scientific Reports, 12, 8387. https://doi.org/10.1038/s41598-022-12331-0
Mann, R., Mackay, F., Pearce, G., Freemantle, S., & Wilton, L. V. (1999). Losartan: A study of pharmacovigilance data on 14,522 patients. Journal of Human Hypertension, 13(8), 551–557. https://doi.org/10.1038/sj.jhh.1000880
Ministerio de Salud Pública. (2018). Encuesta STEPS Ecuador 2018: Informe de resultados. Ministerio de Salud Pública del Ecuador.
Organización Mundial de la Salud. (2025, 25 de septiembre). Hipertensión. https://www.who.int/es/news-room/fact-sheets/detail/hypertension
Organización Panamericana de la Salud. (2023). HEARTS en Ecuador: Un enfoque estratégico para mejorar la gestión de la hipertensión en el primer nivel de atención. https://www.paho.org/es/documentos/hearts-ecuador-enfoque-estrategico-para-mejorar-gestion-hipertension-primer-nivel
Tao, Y., Zhang, H. Y., MacGilchrist, C., Kirwan, E., & McIntosh, C. (2025). Prevalence and risk factors of painful diabetic neuropathy: A systematic review and meta-analysis. Diabetes Research and Clinical Practice, 222, 112099. https://doi.org/10.1016/j.diabres.2025.112099
Weber, M. A. (1997). Clinical safety and tolerability of losartan. Clinical Therapeutics, 19(4), 604–616. https://doi.org/10.1016/S0149-2918(97)80086-0
Yamaura, K., Nelson, A. L., Nishimura, H., Rutledge, J. C., Ravuri, S. K., Bahney, C., Philippon, M. J., & Huard, J. (2023). The effects of losartan or angiotensin II receptor antagonists on cartilage: A systematic review. Osteoarthritis and Cartilage, 31(4), 435–446. https://doi.org/10.1016/j.joca.2022.11.014
Zhang, A. S., Xu, A., Ansari, K., Hardacker, K., Anderson, G., Alsoof, D., & Daniels, A. H. (2023). Lumbar disc herniation: Diagnosis and management. The American Journal of Medicine, 136(7), 645–651. https://doi.org/10.1016/j.amjmed.2023.03.024
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